Defragmenting your disk can take some time (several hours even on a fast PC), and you cannot use your PC during this time. It's advised that you leave your PC defragmenting over night.
Disk
Defragmentor will start. In the top half of the window you will see a list of
your harddisks, you may only have one. If you have several you will need to
defragment each drive. Click on the drive that you wish to defragment and
click Analyse.
After a few seconds you will be told if you need to defragment your disk
or not.
If you do wish to defragment your harddisk then click Defragment. Do
not use your computer while it is defragmenting.
After some hours defragmentation
will be complete. The graphical representation of your harddisk should look
more healthy with little or no red blocks. You may now quit Disk Defragmentor
or defragment another disk.